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Concentration Camps List. Tarrooghyssagh . The letter states that this rule will be strictly enforced in all government Indian schools. The Commissioner of Indian Affairs urges, & very forcibly too, that instruction in their vernacular is not only of no use to them but is detrimental to their speedy education & civilization. French missions in the Great Lakes area, & some villages of Indian converts to Christianity in New England. Eastern Missions. Jesuits: 1. 56. 6- 1. Franciscans operated missions in Florida & Georgia for almost 2. By 1. 65. 5, 3. 8 missions in the area. After the founding of Charleston, S. C., in 1. 67. 0, English settlers enslaved & killed the Indians. By 1. 70. 8, only a few missions were left, & in 1. Spain surrendered Florida to England. Nombre de Dios: Name of the God . Augustine, Florida: Oldest U. S. Missions in 5. Pueblo towns. In early 1.
Indians. 1. 68. 0’s: Adobe & stone missions in San Antonio area known as the Alamo chain. He founded 2. 4 missions. Franciscans came in 1. San Esteban Rey de Acoma . Now San Antonio Missions National Historical Park. Lake Sonoma Valley excavations identified as Amacha. Elder Kashia- Pomo remember their grandfathers hid out from oncoming immigrants in the mid- 1. Amacha. Soldiers took all the people to government lands & burned the village. Franciscan Father Jun. Rumsen Ohlone named Carmele. Kuruvungna Springs, University High School West Los Angeles, burial grounds disturbed by developers & bones broken by archeologists. Puvungna Burial Ground, birthplace of prophet Chingishnish & place of creation, at CSU Long Beach. Developers have repeatedly attempted to build a strip mall since 1. 400 Mile Sale Dates: June 1-4, 2017 If you want to add your sale to the list below, please e-mail us your information. Need a spot to set up? Click here for a listing. Blocked by courts after petition by the Tongva for relief (6. Chumash- Kagismuwas: Coastal Peoples enslaved & killed by Spanish missionaries. Spaniard Gabriel Moraga with 1. Suisuns: People of the South Wind . San Francisco Presidio Commandant Jos. Spaniards gain ground in present- day Fairfield & Suisun, reaching Chief Malica’s village which burst into flames. Earthquake destroyed most of mission in 1. Santa Clara: 8. 0% die in the missions over next 4. Soil used as road & tennis court fill, yard fertilizer & chicken feed. Graverobbers called pothunters. Parks District dealing with a self- published guidebook containing driving & hiking instructions to 4. Ohlone, Bay Miwok, & Northern Valley Yokut sites in violation of the 1. National Historic Preservation Act. New Agers construct shelters, fires on village sites. Chalen Ohlone named Soledad by Spaniards. Franciscan Spaniards enslave Miwok. Miwok hunted for sport by the rich. Uzumaiti: Valley of the Gaping Mouth: Yosemite Valley Miwok who gave their name to the world’s most famous natural playground, only to be run out by settlers in 1. The park bulldozes the last village (1. Tataviam named Ferna. San Diego County in First Military District . Father Ferm. San Jacinto: 2. Guide containing locations of Native American sites in area auctioned to highest bidder. Foot traffic, vandalism, graverobbing, amp; looting follow, according to Bennae Calac, cultural resources director for the Soboba Band of Luise. Marin County named after Licatiut Miwok Chief Marin. Mass grave underneath mission. Indian people at Nicasio, San Rafael. The population was persuaded to leave in the 1. Marin County curtailed funds to all Indians (except those at Marshall) who were not living at the Poor Farm, a place for indigent peoples. Smallpox: Chief Solano one of the few natives to receive a vaccination & worked at Rancho Petaluma Adobe. Sacramento Valley people (El Dorado, Placer, Sacramento- Yolo Counties) die of smallpox. Maidu: Person village of Koloma raided by James Marshall, agent to Sutter who discovers gold. Wintu forced as laborers in gold mining operations. Auburn & Napa Valley newspaper editors & politicians call for immediate extermination of Northern California Indians. Legislature reimbursed the Eel River Rangers & other volunteer militias to do the job (Sac Bee: Gold). California’s legal apprentice system allowed settlers to keep homeless or jobless Indians indentured until they were 3. A good- looking Indian girl cost $1. Marysville Appeal. Federal Indian agents negotiate 1. California tribal leaders. Congress never ratifies the treaties. California Assembly Report: Indians removed. There is no place within the territory of the United States in which to locate them .. Warner. 18. 71: United States Congress concludes tribes no longer separate, independent governments. This action freed the United States from the need to make treaties. Boarding Schools: 1. Indian names. English- only rule: Beaten, latrine duty. Reddick. 19. 24: Indian Citizenship Act: Citizenship to every Indian born within the territorial limits of the United States / US Border Patrol. Blood Quantum. 19. Repatriation Program: 5. U. S. In California they were placed in detention camps & mistreated by government officials. The commissioner of Indian affairs who inaugurated this policy, Dillon Meyer, was principally known as the man responsible for administering Japanese- American concentration camps during World War II. Public swimming pools, rest rooms, drinking fountains, & theaters were often segregated. Mexican American schoolchildren were often forbidden to speak Spanish in schools & were sometimes punished severely for doing so.’1. Native American Graves Protection & Repatriation Act: . Kolata, Ph. D., Prof. Fixico, Ph. D., Prof. Nearly half the nation’s 5. Indian tribes represented in the Bay Area alone. Hispanic Americans are Americans of Spanish- speaking descent. Many are the descendants of Mexican people who lived in the Southwest when it became part of the United States. Almost all others or their ancestors migrated to the United States from Latin America. The 3 largest Hispanic groups in the United States are Mexican Americans, Puerto Ricans, & Cuban Americans. As a group, Hispanic Americans represent a mixture of several ethnic backgrounds, including European, American Indian, & African. Residents of Puerto Rico are U. S. Census Bureau does not count the island’s native residents as part of the U. S. Garcia, Ph. D., Vice Provost for Academic Planning, Baylor University, World Book Encyclopedia . Largest government railroad land grant: vast extinguishment of Indian land titles. Engineering parties protected by George Armstrong Custer. Complete line 1. 88. W. Of course, buildings like the poor farm & its cemetery remain unknown to the historians & the history experts. So it is time that a case is made for this cemetery & the spirits that reside there. No better place to start then this Butte Evening New’s Christmas story nearly a century ago. April 1. 94. 4 im niederl. American slaveowners forced their newly- freed slaves to sign life indenture contracts. Herman Hollerith (b 1. Hollerith starts as a 1. US Census Bureau as part of his education at Columbia University. Part of International Business Machines. The Hollerith name still used in Germany. The machine uses punch cards and is first used to calculate the dead for the local health departments in Maryland, New York & New Jersey. It is then expanded to cover freight accounting for the New York Central Railroad, actuarial records for Prudential Insurance, & the US Census of 1. Between 1. 89. 0 & 1. Hollerith leases the machine at $7. Russian . In 1. 91. Hollerith sells to international commodities: arms & weapons producer Charles Flint, The Merchant of Death & Father of Trusts. Flint sells weapons to Chile, Per. Merit Cross with German Eagle Star from Adolf Hitler at the League of Nations International Chamber of Commerce Meeting in Hamburg. United States Census, Draft, Pacific, Tunisia, Sicily: IBM MRU: Machine Record Units. Endicott, New York trains 1,3. Allied soldiers. After Pearl Harbor, the United States Census Bureau uses punch- card information to identify people of Japanese Heritage. Executive Order 9. Japanese- Americans on the W. Evacuations begin in Los Angeles. The overall dimensions of punched cards used for data processing have remained the same since Herman Hollerith invented the medium: 7 3/8 inches wide by 3 1/4 inches high by . Prior to 1. 92. 9, this was a standard size for many US banknotes. Today, these dimensions are set by the EIA standard RS- 2. This standard is augmented by ANSI X3. ANSI X3. 2. 6- 1. Hollerith code to encode alphanumeric data on cards. When an urban Indian dies, the death certificate rarely lists his or her race correctly, Indian Health Service studies show. California’s urban Indians are unknown, uncountable, an enigma, said Indian Health Service statistician Lorraine Mc. Call. We rarely know who they are, where they are or the status of their health.’ (1. Sacramento Bee). Even the CDIB cards (Certification of Degree of Indian Blood) bear an eerie resemblance to the pass- books used to control non- whites in South Africa. I should stretch & give you a little more medical perspective on the mental illness. A lot of these kids come from bad gene pools. They don’t have stable parents making good decisions, or else most of them would not be in foster care – Dr. Joseph Burkett: Texas Society of Psychiatric Physicians: Houston Chronicle . While in jail, Alice Paul went on a hunger strike, similar to those in which she engaged while a member of the WSPU: Womens’ Social & Political Action Union of Great Britain, in an attempt to win concessions from the government. Brace’s Children’s Aide Society. Thie treoghana: Place that abandons the Divine Young: Orphanage. Orphan Trains for indentured servitude. Children lined up at predetermined stops to be looked over. In 1. 92. 7, 1. 2 states: Wisconsin, Illinois, Michigan, Indiana, Pennsylvania, Arkansas, Massachusetts, Rhode Island, Virginia, West Virginia, Nebraska & Kansas allowed indenture of children turned over to poor farms or county authorities. When official transporting of children ended in 1. Mile Sale - Yard Sale Locations. Grover Lane, Sharpe. Road beside Hwy 6. Variety of items, more added close to the date of sale. Open on Sunday. 5 Family Yard Sale. Lots and lots of stuff, clothing, twin girls matching outfits, boys clothing. Shoes, bathroom sets, lamps, glassware and so much more. Open Rain or Shine. Open Sunday. Mason Hall, Sharpe.(Inside - rain or shine). All antiques, primitives, old buggy bench, baskets, crates, vintage pond boats, vintage fire fighter equipment, furniture, oil lamps, unusual smalls, duck decoys, cast iron banks, and so many other items. Start your treasure shopping with us. Open Thursday - Saturday. Scale Rd., Benton(Sharpe Community). Baby items, womens clothing, shoes, odds and ends, household items, twin comforter bedding set, antique furniture, wall hangings, authentic Coach purses, authentic Kate Spade tote, more items added closer to sale. Open Thursday - Saturday. Scale Road, Benton(Sharpe Community). Vintage Strawberry Shortcake toys, patio furniture, new kerosene heater, new folding camp stove, glassware, misc. Open Thursday - Saturday. US Hwy 6. 8 W, Sharpe. Miscellaneous items including some antiques, also have spaces to rent (indoor and outdoor). Open all 4 days of sale. Hwy 6. 8W, Calvert City (one mile east of Sharpe). Toys and Stuff! Open all 4 days of the sale. Lanview Ave., Paducah(Reidland/Sharpe Area - US Hwy 6. Childrens clothing, toys, furniture, household items. Open Thursday - Saturday. US Hwy 6. 8 East, Benton. Antique, furniture, vintage glass, collectables, household items and clothes. THREE family sale. Open all 4 days. 3. Olive Creek Rd., Benton.(Fairdealing area turn right on first road on the right past Fast Eddies, house is 1/4 down that road.) Womens clothes and shoes, childrens clothing, home decor, toys, jewelry. Open all 4 days. 5. Greenhill Dr., Benton. Double Family Sale! Lots of name brand mens and womens clothing, several household and decorative items, teen clothes also available. Open Thursday. 7. US Hwy 6. 8 W, Benton. Open all 4 days. 8. US Hwy 6. 8 W, Benton. Children's items, toys and clothes, lots of miscellaneous, camper, adult clothing, yard decor, furniture, lots of books, a little of everything - made from scratch homemade concessions. Swing by for a fair deal and a taste of Kentucky! Open Thursday - Saturday. Woodgrove Rd., Benton. Clothes, baby clothes, couponing items, such as shampoo, conditioner, etc. A little bit of everything. Multi- family sale. Victoria's Secret womens clothing (bras), miss me jeans, plus size womens clothing, name brand clothing, prom/pageant dresses, cocktail dresses, baby clothes, various baby items, baby swing, wipes, warmer, diapers, Vera Bradley items, Coach items, humidifier, pillows, steam mop, army clothing and gear, shelves, wedding stuff, bikinis (brand new Hollister), flat iron, charcoal smoker, shopping totes, brand new Medela breast pump, thirty one, coffee pot, NFL Colts jersey, bath and boy works new, home decor, Play. Station 2 games including guitar hero, alarm clock, shoes and high heels, bels, nail polish, scentsy stuff, display rack. Too Much To Mention! Open Thursday - Saturday. Golden Acres Loop, Calvert City (Sharpe Community). Vintage singer dollhouse bedroom furniture (1. Lance jars, 6 Lord Supper plates, desk ruby red basket and bowl, jewelry, Tupperware, books, dvds, wheel barrel, old yard tools, misc., dishes. Large selection of boys clothes (infant to large boys), shoes, cleats, and sports gear (North Face, Under Armour, Nike, Abercrombie & Fitch, Polo, PS Aeropostle, and many more), bikes, toys, furniture, household items. Open Friday & Saturday. Christian Court, Benton. Open Thursday - Saturday. Shawn Drive, Benton(Sharpe Community). Household items, home decor, 2 sets of dishes, girls clothes, girls plus clothes, toys, womens shoes and much more. Open Friday and Saturday. Oakland CP Church, 9. US Hwy 6. 8W., Calvert City. Yard Sale on Friday - Saturday. Food on Saturday only. Have participated for 5- 6 years. Open Friday and Saturday. Wildwood Lane, Benton. Clothing, vintage mirrored dresser trays, books, home decor, flower- girl wagon, misc. Open Friday and Saturday. Vicksburg Estate Road, Benton. Remodel sale: Lots of interior products, plants, clothes, 5 Families of stuff! Open all 4 days. 6. Bluejay Lane, Benton (dead end road). Household items, kids clothing, crocheted blankets, toys, figurines, furniture, tires, wheels and more. Multiple families set up. Open all 4 days of sale. Deerfield, Benton. Shaved ice, lemon shake- ups, cotton candy, hot dogs and a variety of drinks. Open Thursday - Saturday. Lakeside Drive, Benton (Parkview Estates next to Mike Miller Park). Moving sale. Clothes, knick- knacks, electronics, furniture, lots of holiday decorations, toys, books, movies, cds/dvds, games. Open all 4 days of sale. Will also have a food truck with hotdogs, drinks, shaved ice, cookies, caramel apples, and cotton candy. Deerfield Circle, Benton.(Draffenville Community next to Mike Miller Park). Clothes, home goods, toys, antiques, collectibles, and much more. Open Thursday - Saturday. Hwy 6. 8 E., Benton (2- 1/2 miles from Hwy 6. Y at Draffenville going east). Large sale of antiques, collectibles, furniture, and much more. Open all 4 days of sale. Baby boy clothes and shoes, toys, bedding, womens clothing, household odds and ends, & changing table. Open Friday and Saturday only. Shawn Drive, Benton. Lots of children's clothing. Open Thursday - Saturday. US Hwy 6. 8E, Benton. Outside Draffenville by the Forgotten Past. Wood furniture, handmade crafts, and multi- family yard sale items, can drinks, and chips. Open all 4 days of sale. Mission Oak Sette, antiques, books, glassware, furniture, misc. Open Thursday - Saturday. Hwy 6. 8 East, Benton. Baby boy clothes, bibs, bottles, shoes, tools, womens clothing and shoes. Open all 4 days. 6. Highway 6. 8E., Benton. Open all 4 days of sale. Benton Birmingham Road, Benton. Multi- family sale. Lots of boys and girls items, toys, household items, and lots more. Open all 4 days of sale. US Hwy 6. 8W, Benton. Open all 4 days of the sale. Assorted items plus a free pile. Don't want to miss! Boatright Dr., Benton(Palma/Draffenville area, just off Hwy 9. North Marshall Middle School). Kids toys, clothes, baby items, lawn furniture, headboard/footboard, bedrails, home decor, gun cabinet, golf cart wheels/tires. Thursday - Saturday. US Hwy 6. 8E., Benton. Multi- family (5 families) yard sale. Thursday - Saturday. Household items, refreigerator, sink, swimming pool items, home decor, kitchen items, pool table, books, scrap booking, electronics, games, office desk, kids toys, name brand girls clothes and shoes in wide range of sizes, name brand baby boy clothes up to size 5, name brand mens and womens clothes and shoes, lots of baby items (changing table, blankets, bottle accessories, etc.) baby toys, and lots more. Furniture, dishware, kitchen items, decor, holiday items, antiques and more. Open Thursday - Saturday. DONT WAIT AND DONT MONKEY AROUND UNTIL YOU CHECK OUT OUR HUGE GARAGE SALE. ANTIQUES: dishes, vases, jugs, books, x- mas, toys, etc. BOOKS: hard cover and soft. CRYSTAL: plates, vases, bowls, platters, glasses, etc. CRAFT SUPPLIES: thread, needles, floral, etc. ELECTRONICS: speakers, receivers, cassettes, vhs, etc. FURNITURE: kitchen tables, desk, lamps, coffee table, end table. HOUSEWARES: blankets, pillows, bed spreads and comforters, rugs. KITCHENWARE: everything you could need. LAWN/GARDEN: chairs, water pump, trimmers, tools, water decor, etc. TOOLS: screwdrivers, flashlites, tape measures, tarps, tool organizers. TOYS: Tonka trucks, stuffed animals, games, books. All 3 garages can be seen from US 6. Thursday - Saturday. Upfront Auto Sale, 2. US Hwy 6. 8E, Benton. Antiques, household, kids clothes, adult clothes, old antique disc, old Dayton Peanut Roaster, men's stuff. A little of everything. About 8- 1. 0 families set up here. Open all 4 days. 4. Dusty Trail, Benton. Rain or shine: baby girl items, 2. Open all 4 days. 5. Greenhill Dr., Benton. Lots of clothes, shoes and business style clothes. Several decorative items. Open Thursday. 6. Cypress Road, Benton. Kerosene heater, 1. Craftsman chop saw, some electrical supplies, snow blower, assorted hand tools, 3. Boys size newborn to 8. Mens and womens clothing, girls newborn to 3. T, shoes, toys, furniture, bikes. Open all 4 days of sale. Moors Camp Highway, Benton. Antique glassware, antique crafts, milk cans, insulation rolls, nice kids rattan cane chair bought in Indonesia, poppason swivel chair, tools, USA made vise, GUNS, gun accessories, ICE COLD water bottles - 5. DVDs, small varmit trap, trailer tire, wheelbarrow tire, garden tools, glassware, ALSO BUY GUNS, small personal safe, video games, and a whole lot more. BIG Sale and we want it all GONE! First house on the right on Moors Camp Highway, Benton. Open all 4 days from 7 am - 6 pm. Please NO early birds, unless saw horse at the end of driveway is down. Open all 4 days. 3. Big Bear Highway, Benton (Malcom Creek Subdivision near Big Bear Resort). Multi- family yard sale. Lots of automotive items, household items, too many items to mention. Open Thursday through Saturday. Woodridge Drive, Benton. Open Thursday - Saturday. Deerfield, Benton.(Right outside Draffenville- in subdivision next to Mike Miller Park). Boys clothing, toddler clothing, toys, household items, shoes, womens clothing, mens clothing including suits and dress pants. Open Thursday - Saturday. Deerfield, Benton(located next to Mike Miller in Parkview Estates). Clothing mostly boutique and name brands, also have a lot of motorcycle goodies (leather, rainsuits, jackets, and Harley t- shirts). 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Tucked away in the center of Santa Barbara lies a piece of Santa Barbara history and one of its most unique jewels. In true Santa Barbara. Side Effects, Interactions, Warning, Dosage & Uses. CLINICAL PHARMACOLOGYGeneral. Propranolol is a nonselective beta- adrenergic receptor blocking agent possessing no other autonomic nervous system activity. It specifically competes with beta- adrenergic receptor agonist agents for available receptor sites. When access to beta- receptor sites is blocked by propranolol, the chronotropic, inotropic, and vasodilator responses to beta- adrenergic stimulation are decreased proportionately. At dosages greater than required for beta blockade, propranolol also exerts a quinidine- like or anesthetic- like membrane action, which affects the cardiac action potential. The significance of the membrane action in the treatment of arrhythmias is uncertain. Mechanism of Action. The mechanism of the antihypertensive effect of propranolol has not been established. Factors that may contribute to the antihypertensive action include: (1) decreased cardiac output, (2) inhibition of renin release by the kidneys, and (3) diminution of tonic sympathetic nerve outflow from vasomotor centers in the brain. Although total peripheral resistance may increase initially, it readjusts to or below the pretreatment level with chronic use of propranolol. Effects of propranolol on plasma volume appear to be minor and somewhat variable. In angina pectoris, propranolol generally reduces the oxygen requirement of the heart at any given level of effort by blocking the catecholamine- induced increases in the heart rate, systolicblood pressure, and the velocity and extent of myocardial contraction. Propranolol may increase oxygen requirements by increasing left ventricularfiber length, end diastolic pressure, and systolic ejection period. The net physiologic effect of beta- adrenergic blockade is usually advantageous and is manifested during exercise by delayed onset of pain and increased work capacity. Propranolol exerts its antiarrhythmic effects in concentrations associated with beta- adrenergic blockade, and this appears to be its principal antiarrhythmic mechanism of action. In dosages greater than required for beta blockade, propranolol also exerts a quinidine- like or anesthetic- like membrane action, which affects the cardiac action potential. The significance of the membrane action in the treatment of arrhythmias is uncertain. The mechanism of the antimigraine effect of propranolol has not been established. Beta- adrenergic receptors have been demonstrated in the pial vessels of the brain. The specific mechanism of propranolol's antitremor effects has not been established, but beta- 2 (noncardiac) receptors may be involved. A central effect is also possible. Clinical studies have demonstrated that Inderal (propranolol) is of benefit in exaggerated physiological and essential (familial) tremor. Pharmacokinetics And Drug Metabolism Absorption. Propranolol is highly lipophilic and almost completely absorbed after oral administration. However, it undergoes high first- pass metabolism by the liver and on average, only about 2. Peak plasma concentrations occur about 1 to 4 hours after an oral dose. Administration of protein- rich foods increase the bioavailability of propranolol by about 5. Distribution. Approximately 9. The binding is enantiomer- selective. AskMen's Dating channel offers you all the advice you need to become a Better Man in romance and relationships. The Urban Dictionary Mug. One side has the word, one side has the definition. Microwave and dishwasher safe. Lotsa space for your liquids. Buy the mug. Stick Games has all the best Action, Shooting, Defense, Strategy and Guts & Gore stick games online. Blonde milf with big round tits fucked on the office table. Brunette seductress Angell Summers fucked in anal and snatch. FLING.COM - World's Best Adult Personals for adult dating, search millions of adult personals from singles, couples, and swingers looking for fun, browse sexy photos. This Man Is Dating Someone Even Though He's Married. Sounds Disgusting, But I'm On His Side. Simgirls (full version), the most popular online dating sim game. Dating games offer a little love practice and a lot of fantasy fulfillment – whether that's wild romance or naughty adventures. The S(- )- enantiomer is preferentially bound to alpha. R(+)- enantiomer preferentially bound to albumin. The volume of distribution of propranolol is approximately 4 liters/kg. Propranolol crosses the blood- brain barrier and the placenta, and is distributed into breast milk. Metabolism and Elimination. Propranolol is extensively metabolized with most metabolites appearing in the urine. Propranolol is metabolized through three primary routes: aromatic hydroxylation (mainly 4- hydroxylation), N- dealkylation followed by further side- chain oxidation, and direct glucuronidation. It has been estimated that the percentage contributions of these routes to total metabolism are 4. The four major metabolites are propranolol glucuronide, naphthyloxylactic acid and glucuronic acid, and sulfate conjugates of 4- hydroxy propranolol. In vitro studies have indicated that the aromatic hydroxylation of propranolol is catalyzed mainly by polymorphic CYP2. D6. Side- chain oxidation is mediated mainly by CYP1. A2 and to some extent by CYP2. D6. 4- hydroxy propranolol is a weak inhibitor of CYP2. D6. Propranolol is also a substrate of CYP2. C1. 9 and a substrate for the intestinal efflux transporter, p- glycoprotein (p- gp). Studies suggest however that p- gp is not dose- limiting for intestinal absorption of propranolol in the usual therapeutic dose range. In healthy subjects, no difference was observed between CYP2. D6 extensive metabolizers (EMs) and poor metabolizers (PMs) with respect to oral clearance or elimination half- life. Partial clearance of 4- hydroxy propranolol was significantly higher and of naphthyloxyactic acid significantly lower in EMs than PMs. The plasma half- life of propranolol is from 3 to 6 hours. Enantiomers. Propranolol is a racemic mixture of two enantiomers, R(+) and S(- ). The S(- )- enantiomer is approximately 1. R(+)- enantiomer in blocking beta adrenergic receptors. In normal subjects receiving oral doses of racemic propranolol, S(- )- enantiomer concentrations exceeded those of the R(+)- enantiomer by 4. Clearance of the pharmacologically active S(- )- propranolol is lower than R(+)- propranolol after intravenous and oral doses. Special Populations. Geriatric. In a study of 1. S(- )- enantiomer of propranolol was decreased in the elderly. Additionally, the half- life of both the R(+)- and S(- )- propranolol were prolonged in the elderly compared with the young (1. Clearance of propranolol is reduced with aging due to decline in oxidation capacity (ring oxidation and side- chain oxidation). Conjugation capacity remains unchanged. In a study of 3. 2 patients age 3. HP- ring oxidation) and to naphthoxylactic acid (NLA- side chain oxidation). No correlation was found between age and the partial metabolic clearance to propranolol glucuronide (PPLG- conjugation). Gender. In a study of 9 healthy women and 1. In contrast, there was a significant, although non- enantioselective diminution of the binding of propranolol after treatment with ethinyl estradiol. These findings are inconsistent with another study, in which administration of testosterone cypionate confirmed the stimulatory role of this hormone on propranolol metabolism and concluded that the clearance of propranolol in men is dependent on circulating concentrations of testosterone. In women, none of the metabolic clearances for propranolol showed any significant association with either estradiol or testosterone. Race. A study conducted in 1. Caucasian and 1. 3 African- American male subjects taking propranolol, showed that at steady state, the clearance of R(+)- and S(- )- propranolol were about 7. African- Americans than in Caucasians, respectively. Chinese subjects had a greater proportion (1. Caucasians, which was associated with a lower plasma concentration of alpha. Renal Insufficiency. In a study conducted in 5 patients with chronic renal failure, 6 patients on regular dialysis, and 5 healthy subjects, who received a single oral dose of 4. Cmax) of propranolol in the chronic renal failure group were 2 to 3- fold higher (1. Propranolol plasma clearance was also reduced in the patients with chronic renal failure. Studies have reported a delayed absorption rate and a reduced half- life of propranolol in patients with renal failure of varying severity. Despite this shorter plasma half- life, propranolol peak plasma levels were 3- 4 times higher and total plasma levels of metabolites were up to 3 times higher in these patients than in subjects with normal renal function. Chronic renal failure has been associated with a decrease in drug metabolism via downregulation of hepatic cytochrome P4. In a study conducted in 7 patients with cirrhosis and 9 healthy subjects receiving 8. In cirrhosis, the half- life increased to 1. PRECAUTIONS). Drug Interactions Interactions with Substrates, Inhibitors or Inducers of Cytochrome P- 4. Enzymes Because propranolol's metabolism involves multiple pathways in the cytochrome P- 4. CYP2. D6, 1. A2, 2. C1. 9), co- administration with drugs that are metabolized by, or effect the activity (induction or inhibition) of one or more of these pathways may lead to clinically relevant drug interactions (see DRUG INTERACTIONS under PRECAUTIONS). Substrates or Inhibitors of CYP2. D6. Blood levels and/or toxicity of propranolol may be increased by co- administration with substrates or inhibitors of CYP2. D6, such as amiodarone, cimetidine, delavudin, fluoxetine, paroxetine, quinidine, and ritonavir. No interactions were observed with either ranitidine or lansoprazole. Substrates or Inhibitors of CYP1. A2. Blood levels and/or toxicity of propranolol may be increased by co- administration with substrates or inhibitors of CYP1. A2, such as imipramine, cimetidine, ciprofloxacin, fluvoxamine, isoniazid, ritonavir, theophylline, zileuton, zolmitriptan, and rizatriptan. Substrates or Inhibitors of CYP2. C1. 9Blood levels and/or toxicity of propranolol may be increased by co- administration with substrates or inhibitors of CYP2. C1. 9, such as fluconazole, cimetidine, fluoxetine, fluvoxamine, tenioposide, and tolbutamide. No interaction was observed with omeprazole. Inducers of Hepatic Drug Metabolism. Blood levels of propranolol may be decreased by co- administration with inducers such as rifampin, ethanol, phenytoin, and phenobarbital. Cigarette smoking also induces hepatic metabolism and has been shown to increase up to 7. Cardiovascular Drugs Antiarrhythmics. The AUC of propafenone is increased by more than 2. The metabolism of propranolol is reduced by co- administration of quinidine, leading to a two- three fold increased blood concentration and greater degrees of clinical beta- blockade. The metabolism of lidocaine is inhibited by co- administration of propranolol, resulting in a 2. Calcium Channel Blockers. |
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